![]() This type of seizure affects the entire body, causing muscle rigidity, convulsions, and loss of consciousness. ![]() Affected individuals can also experience generalized tonic-clonic seizures (also known as grand mal seizures). Often the first type to occur are febrile seizures, which are triggered by a high fever. Several different types of seizures can occur in this disorder, even in the same individual. Many people with BPAN have recurrent seizures (epilepsy) beginning in infancy or early childhood. For this reason, BPAN is classified as a type of disorder called neurodegeneration with brain iron accumulation (NBIA), although the iron accumulation may not occur until late in the disease. ![]() ![]() Affected individuals develop a buildup of iron in the brain that can be seen with medical imaging. Beta-propeller protein-associated neurodegeneration (BPAN) is a disorder that damages the nervous system and is progressive, which means that it gradually gets worse.
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